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Chaos / Volume 21 / Issue 4 / REGULAR ARTICLES

Chaos 21, 043135 (2011); http://dx.doi.org/10.1063/1.3665091 (8 pages)

Modeling of relay helix functional dynamics and feasibility of experimental verification by neutron scattering

Miljko V. Satarić1, Slobodan Zdravković2, and Jack A. Tuszyński3,4

1Fakultet tehničkih nauka, Univerzitet u Novom Sadu, 21000 Novi Sad, Serbia
2Institut za nuklearne nauke Vinča, Univerzitet u Beogradu, Poštanski fah 522, 11001 Belgrade, Serbia
3Department of Physics, University of Alberta, Edmonton, Alberta T6G 2J1, Canada
4Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada

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(Received 2 June 2011; accepted 10 November 2011; published online 22 December 2011)

Cellular long-range transport involves motor proteins (MPs) (especially, kinesin and myosin) which contain a so-called relay helix. Its motion is of crucial importance to the conversion of chemical energy released in ATP hydrolysis into the coordinated mechanical movement of the entire motor protein. In this paper, we propose two combined nonlinear mechanisms for this particular functional activity and suggest the application of neutron scattering assays to experimentally determine the incoherent dynamic structure factor S(q,ω). We argue that this type of experiment is not only feasible but it could offer significant insights into the mechanism of MP function at a molecular level.

© 2011 American Institute of Physics

Article Outline

  1. INTRODUCTION
  2. NONLINEAR POTENTIALS UNDERLYING RH FUNCTIONAL DYNAMICS
  3. RELAY HELIX DYNAMICS IN THE CONTEXT OF THE MODE-COUPLING THEORY
  4. NEUTRON SCATTERING AS A POSSIBLE PROBE FOR RH DYNAMICS IN KINESIN MP
  5. CONCLUSIONS

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KEYWORDS and PACS

Keywords

cellular transport, molecular biophysics, neutron diffraction, proteins

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3665091

PUBLICATION DATA

ISSN

1054-1500 (print)  
1089-7682 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    A. Xie, A. F. G. van der Meer and R. H. Austin, Phys. Rev. Lett. 88(1), 018102 (2002).

    M. V. Satarić, L. Matsson, and J. A. Tuszyński, Phys. Rev. E 74, 051902 (2006).

    S. Zdravković and M. V. Satarić, Phys. Rev. E 77, 031906 (2008).

    W. Z. Wang, J. T. Gammel, A. R. Bishop, and M. I. Salkola, Phys. Rev. Lett. 76, 3598 (1996).

    M. V. Satarić, S. Zeković, J. A. Tuszyński, and J. Pokorny, Phys. Rev. E 58, 6333 (1998).

    M. V. Satarić and J. A. Tuszyński, Phys. Rev. E 67, 011901 (2003).

    M. A. Collins, A. Blumen, J. F. Currie, and J. Ross, Phys. Rev. B 19, 3630 (1978).

    J. Edler, R. Pfister, V. Pouthier, C. Falvo, and P. Hamm, Phys. Rev. Lett. 93, 106405 (2004).


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